Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 7/20 | 0.54 |
| ▸ | PYGL | P06737 | 1/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210425 | 0.90 | EPHX2 (0.51) | PTGER4PTGER2EPHX2PPARGKMT2A | |
| SCHEMBL8206605 | 0.88 | NPC1 (0.48) | PTGER4PTGER2EPHX2PPARGKMT2A | |
| SCHEMBL7888441 | 0.87 | PTGER4 (0.53) | PTGER4PYGLPTGER2EPHX2PPARG | |
| SCHEMBL7890829 | 0.85 | GRIN2C (0.56) | PTGER4PYGLPTGER2EPHX2PPARG | |
| SCHEMBL7890903 | 0.82 | NR1H4 (0.57) | KMT2ANR1H4LMNAL3MBTL1 | |
| SCHEMBL7888438 | 0.81 | ROCK2 (0.52) | PTGER4EPHX2KMT2ANR1H4LMNA | |
| SCHEMBL8199987 | 0.81 | LMNA (0.57) | KMT2ALMNA | |
| SCHEMBL8206330 | 0.79 | MEN1 (0.50) | PPARGKMT2ALMNAL3MBTL1 | |
| SCHEMBL7887105 | 0.79 | SMN1; SMN2 (0.43) | PTGER4PPARGKMT2ACYP1A2CYP2C19 | |
| SCHEMBL7888363 | 0.79 | RAB9A (0.51) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |