Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7888341 | 0.90 | NR1H4 (0.50) | CYP2C19KMT2ANR1H4LMNAEPHX2 | |
| SCHEMBL8207400 | 0.89 | CNR2 (0.49) | PTGER4PTGER2CYP1A2CYP2C19KMT2A | |
| SCHEMBL7890829 | 0.87 | GRIN2C (0.56) | PTGER4PTGER2CYP1A2CYP2C19KMT2A | |
| SCHEMBL7889377 | 0.87 | PTGER4 (0.54) | PTGER4PTGER2CYP1A2CYP2C19KMT2A | |
| SCHEMBL7892988 | 0.83 | NR1H4 (0.58) | KMT2ANR1H4 | |
| SCHEMBL7881130 | 0.81 | TDP1 (0.60) | KMT2ALMNA | |
| SCHEMBL7422687 | 0.81 | LMNA (0.50) | PTGER4KMT2ANR1H4LMNAEPHX2 | |
| SCHEMBL8210714 | 0.80 | KDM4E (0.51) | CYP1A2CYP2C19KMT2ALMNAL3MBTL1 | |
| SCHEMBL7429703 | 0.79 | MMP13 (0.43) | CYP1A2CYP2C19KMT2ALMNA | |
| SCHEMBL7888490 | 0.79 | RAB9A (0.54) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |