Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899197 | 0.78 | DPP4 (0.43) | HSD11B1 | |
| SCHEMBL7899195 | 0.78 | DPP4 (0.43) | HSD11B1 | |
| SCHEMBL7898092 | 0.75 | DRD2 (0.45) | LMNAALDH1A1 | |
| SCHEMBL31569180 | 0.75 | MEN1 (0.42) | POLBKDM4EGPR119MEN1KMT2A | |
| SCHEMBL29757597 | 0.75 | MEN1 (0.42) | POLBKDM4EGPR119MEN1KMT2A | |
| SCHEMBL16182188 | 0.73 | HSD11B1 (0.46) | POLBKDM4EGPR119HSD11B1NPC1 | |
| SCHEMBL4598233 | 0.73 | ACE (0.41) | POLBKDM4EGPR119MEN1KMT2A | |
| SCHEMBL21743930 | 0.73 | MEN1 (0.43) | POLBKDM4EGPR119MEN1KMT2A | |
| SCHEMBL4597855 | 0.73 | HDAC8 (0.43) | POLBKDM4EGPR119MEN1KMT2A | |
| SCHEMBL12178872 | 0.72 | GPR119 (0.44) | POLBKDM4EGPR119HSD11B1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184229-B1 | 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy | SANOFI-SYNTHELABO (FR) | 2001-02-06 | — | — | US | disclosed |