Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561984 | 0.88 | ALOX5 (0.43) | ALOX5LMNANPC1RAB9AMAPT | |
| SCHEMBL9380924 | 0.82 | ALOX5 (0.43) | ALOX5LMNANPC1RAB9AMAPT | |
| SCHEMBL3567445 | 0.79 | ALOX5 (0.43) | ALOX5MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL3574382 | 0.78 | ALOX5 (0.46) | ALOX5KMT2A | |
| SCHEMBL3572528 | 0.78 | ALOX5 (0.41) | ALOX5LMNANPC1RAB9AMAPT | |
| SCHEMBL7809060 | 0.75 | KMT2A (0.41) | ALOX5KMT2A | |
| SCHEMBL7807422 | 0.75 | ALOX5 (0.44) | ALOX5NPC1RAB9AMAPTTDP1 | |
| SCHEMBL7811821 | 0.74 | ALOX5 (0.42) | ALOX5KMT2A | |
| SCHEMBL332725 | 0.74 | ALOX5 (0.53) | ALOX5KMT2A | |
| SCHEMBL1598952 | 0.73 | ALOX5 (0.35) | ALOX5LMNARAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194585-B1 | REACTING 4-(3-(4-(2-(ALKYL OR ARYL-IMIDAZOL-1-YL)-PHENYL SULFANYL)-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID AMIDE WITH METHANESULFONIC ACID TO FORM CORRESPONDING METHANESULFONIC ACID | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1029865-A2 | Process and intermediates for preparing 5-lipoxygenase inhibitors | Pfizer Products Inc. (US) | 2000-08-23 | — | — | EP | disclosed |