Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381713 | 0.86 | LMNA (0.38) | ALOX5MAPTRAB9ANPC1LMNA | |
| SCHEMBL9380088 | 0.85 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL9049501 | 0.85 | HPGD (0.47) | ALOX5MAPTRAB9ANPC1CYP2C9 | |
| SCHEMBL9251380 | 0.85 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9380927 | 0.83 | ALOX5 (0.63) | ALOX5 | |
| SCHEMBL7892149 | 0.82 | ALOX5 (0.42) | ALOX5MTNR1AMTNR1BMAPTRAB9A | |
| SCHEMBL9440209 | 0.81 | ALOX5 (0.43) | ALOX5MAPTNPSR1 | |
| SCHEMBL9268618 | 0.81 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9384495 | 0.80 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL9440429 | 0.80 | ALOX5 (0.44) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409413-B1 | Diaryl ether heterocycles | ICI PLC (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5208259-A | Lipoxygenase enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES (GB) | 1993-05-04 | — | — | US | disclosed |
| EP-0409413-A2 | Diaryl ether heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |