Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.52 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14184605 | 0.83 | RAB9A (0.53) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10087862 | 0.81 | TRPC3 (0.60) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL806599 | 0.77 | TRPC3 (0.58) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2873347 | 0.76 | ALDH1A1 (0.50) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16586316 | 0.76 | GAA (0.63) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2877955 | 0.75 | DHODH (0.55) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19667972 | 0.72 | NPC1 (0.40) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL22053468 | 0.72 | GAA (0.40) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2878623 | 0.72 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL807014 | 0.72 | TRPC3 (0.73) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |