Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 3/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LIPC | P11150 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807212 | 0.82 | PIK3CD (0.46) | KCNH2JAK2PIK3CDPIK3R1LRRK2 | |
| SCHEMBL807280 | 0.81 | PIK3CD (0.50) | KCNH2PIK3CDPIK3R1CSF1RPIK3CA | |
| SCHEMBL806789 | 0.79 | PIK3CD (0.50) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL789847 | 0.77 | JAK2 (0.46) | KCNH2JAK2ATRPIK3CDPIK3CA | |
| SCHEMBL14247596 | 0.69 | BMPR1B (0.44) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL807223 | 0.67 | IRAK4 (0.46) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL14247756 | 0.67 | BRD4 (0.44) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL14317285 | 0.66 | BMPR1B (0.43) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL9954675 | 0.66 | PI4KA (0.61) | — | |
| SCHEMBL14247512 | 0.66 | PIK3CB (0.42) | KCNH2ATRPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |