Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8751778 | 0.85 | L3MBTL1 (0.47) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL93705 | 0.83 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL9798227 | 0.83 | KDM4E (0.36) | ALDH1A1L3MBTL1CYP1A2CYP2C19TDP1 | |
| SCHEMBL27641064 | 0.81 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL8341638 | 0.81 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7329822 | 0.79 | CA1 (0.39) | ALDH1A1L3MBTL1CYP1A2TDP1LMNA | |
| SCHEMBL21546356 | 0.78 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL6672651 | 0.77 | TSHR (0.50) | L3MBTL1CYP1A2CYP2C19TDP1LTA4H | |
| SCHEMBL8340540 | 0.77 | LMNA (0.40) | ALDH1A1L3MBTL1MAPTNPSR1GLA | |
| SCHEMBL23907055 | 0.76 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1CYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | claimed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | claimed |
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | disclosed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | disclosed |
| US-20130267680-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | STICHTING HET NEDERLANDS KANKERINSTITUUT | 2013-10-10 | — | — | US | disclosed |
| EP-2616479-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | Stichting Het Nederlands Kanker Instituut (NL) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012036551-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | STICHTING HET NEDERLANDS KANKERINSTITUUT (NL) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267680-A1 | TOTAL CHEMICAL SYNTHESIS OF UBIQUITIN, UBIQUITIN MUTANTS AND DERIVATIVES THEREOF | UBQLN1, UBQLN2, UBE3A | ALDH1A1 2827/4885L3MBTL1 610/4885CYP1A2 2784/4885 |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | TPD52L2, TRDMT1, MCTS1 | ALDH1A1 2399/4885L3MBTL1 46/4885CYP1A2 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.