Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16594410 | 1.00 | HDAC6 (0.37) | HDAC6PTGS1NR1I2PGRADORA3 | |
| SCHEMBL12743336 | 0.92 | HDAC6 (0.41) | HDAC6HDAC1HDAC2ALDH1A1TDP1 | |
| SCHEMBL883432 | 0.92 | HDAC6 (0.41) | HDAC6HDAC1HDAC2ALDH1A1TDP1 | |
| SCHEMBL3139219 | 0.92 | HDAC6 (0.41) | HDAC6HDAC1HDAC2ALDH1A1TDP1 | |
| SCHEMBL3698014 | 0.84 | HDAC6 (0.37) | HDAC6HDAC1HDAC2ELANECTSK | |
| SCHEMBL15121261 | 0.83 | ALDH1A1 (0.46) | PTGS1NR1I2PGRADORA3PTGS2 | |
| SCHEMBL14775231 | 0.83 | ALDH1A1 (0.46) | PTGS1NR1I2PGRADORA3PTGS2 | |
| SCHEMBL6016032 | 0.82 | HDAC6 (0.41) | HDAC6HDAC1HDAC2ELANECTSK | |
| SCHEMBL6016036 | 0.82 | HDAC6 (0.41) | HDAC6HDAC1HDAC2ELANECTSK | |
| SCHEMBL4757856 | 0.80 | ATM (0.43) | HDAC6ALDH1A1TSHRTDP1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162905-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | ENANTA PHARM INC (US) | 2018-06-14 | — | — | US | disclosed |
| US-20170088583-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | ENANTA PHARM INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-9439422-B2 | Use of macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2016-09-13 | — | — | US | disclosed |
| EP-3052490-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | Dow AgroSciences LLC (US) | 2016-08-10 | — | — | EP | disclosed |
| EP-3052491-A1 | USE OF MACROCYLIC PICOLINAMIDES AS FUNGICIDES | Dow AgroSciences LLC (US) | 2016-08-10 | — | — | EP | disclosed |
| US-9220748-B2 | Macrocyclic proline derived HCV serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9179674-B2 | Macrocyclic picolinamide compounds with fungicidal activity | DOW AGROSCIENCES LLC (US) | 2015-11-10 | — | — | US | disclosed |
| WO-2015050819-A1 | USE OF MACROCYLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015050818-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150094340-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2015-04-02 | — | — | US | disclosed |
| US-20150094339-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC | 2015-04-02 | — | — | US | disclosed |
| US-20140194350-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-20120070416-A1 | Macrocyclic Proline Derived HCV Serine Protease Inhibitors | ENANTA PHARMACEUTICALS, INC. | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088583-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | PREP, PRSS1, PEPD | HDAC6 731/4885PTGS1 697/4885NR1I2 1036/4885 |
| US-20150094339-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | FKBP1A, FKBP14, FKBP2 | HDAC6 113/4885PTGS1 1826/4885NR1I2 538/4885 |
| US-20120070416-A1 | Macrocyclic Proline Derived HCV Serine Protease Inhibitors | PREP, PRSS1, PEPD | HDAC6 731/4885PTGS1 697/4885NR1I2 1036/4885 |
| US-20140194350-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | PREP, PRSS1, PEPD | HDAC6 731/4885PTGS1 697/4885NR1I2 1036/4885 |
| US-20150094340-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, CYP4F12, CYP1A2 | HDAC6 434/4885PTGS1 2947/4885NR1I2 167/4885 |
| US-20180162905-A1 | MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS | PREP, PRSS1, PEPD | HDAC6 731/4885PTGS1 697/4885NR1I2 1036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.