Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL3220683 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRCA4THRBCA1 | |
| Methacrylic Acid SCHEMBL3220557 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRCA4THRBCA1 | |
| Bicarbonate SCHEMBL28267756 | 0.90 | ALDH1A1 (0.79) | ALDH1A1TSHRCA4THRBCA1 | |
| Methacrylic Acid SCHEMBL3220692 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TSHRCA4THRB | |
| SCHEMBL10636466 | 0.89 | — | — | |
| SCHEMBL27466495 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRTHRBTDP1HSD17B10 | |
| SCHEMBL4390490 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRTHRBTDP1HSD17B10 | |
| SCHEMBL1849 | 0.89 | — | — | |
| SCHEMBL8627821 | 0.86 | — | — | |
| Ethylene SCHEMBL44117 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6190703-B1 | PREPARING SOLVENT SOLUTION BY DISSOLVING SURFACTANT IN WATER OR MIXTURE OF WATER WITH WATER-SOLUBLE SOLVENT; HEATING; MIXING WITH PROPOLIS MASS AND/OR AN EXTRACTION RESIDUE TO FORM SUSPENSION; ADDING HYDROPHILIC POLYMER, HOMOGENEOUSLY MIXING | HAMANAKA HIROYOSHI (JP) | 2001-02-20 | — | — | US | disclosed |