Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138553 | 0.81 | CA1 (0.43) | KDM4EALDH1A1GAA | |
| SCHEMBL8173016 | 0.76 | RXRA (0.42) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL18114066 | 0.75 | KDM4E (0.35) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL18114021 | 0.75 | PTGS2 (0.45) | KDM4EALDH1A1 | |
| SCHEMBL18114067 | 0.74 | INPPL1 (0.43) | KDM4EALDH1A1 | |
| SCHEMBL12680655 | 0.72 | ALDH1A1 (0.46) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL18121309 | 0.71 | ALDH1A1 (0.56) | KDM4EALDH1A1NR1I2HSD11B1MAPT | |
| SCHEMBL7897761 | 0.70 | CA2 (0.38) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL18121465 | 0.70 | NPSR1 (0.36) | ALDH1A1RXRARXRBRXRGGAA | |
| SCHEMBL18114042 | 0.70 | L3MBTL1 (0.48) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |