Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16061102 | 0.84 | LTA4H (0.35) | CYP2D6L3MBTL1ATMPPARALTA4H | |
| SCHEMBL8983426 | 0.78 | PREP (0.36) | CYP2D6L3MBTL1ATMLTA4HRIPK1 | |
| SCHEMBL2368966 | 0.74 | PREP (0.45) | ALDH1A1CYP2D6L3MBTL1ATMLTA4H | |
| SCHEMBL8946199 | 0.71 | PPARA (0.41) | PPARALTA4HPREP | |
| Methylamine SCHEMBL7237290 | 0.71 | PREP (0.42) | CYP2D6L3MBTL1ATMLTA4HRIPK1 | |
| SCHEMBL46390 | 0.69 | ALDH1A1 (0.43) | ALDH1A1RECQLCYP2D6L3MBTL1PPARA | |
| SCHEMBL23930415 | 0.69 | ALDH1A1 (0.41) | ALDH1A1RECQLLTA4HLMNACA4 | |
| SCHEMBL13752559 | 0.68 | NR1H2 (0.33) | RIPK1TSHR | |
| SCHEMBL18417888 | 0.67 | ALDH1A1 (0.40) | ALDH1A1CYP2D6L3MBTL1ATMLTA4H | |
| Bromide SCHEMBL9718079 | 0.67 | ATM (0.35) | CYP2D6L3MBTL1ATMLTA4HRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |