Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27422130 | 0.69 | OPRM1 (0.34) | — | |
| SCHEMBL7458612 | 0.69 | OPRM1 (0.34) | — | |
| SCHEMBL7356160 | 0.67 | CHRNB4 (0.33) | — | |
| SCHEMBL1635517 | 0.65 | — | — | |
| SCHEMBL27422134 | 0.65 | HSD11B1 (0.34) | OPRK1 | |
| SCHEMBL4781128 | 0.65 | HSD11B1 (0.34) | OPRK1 | |
| SCHEMBL9020428 | 0.64 | HTR2A (0.40) | — | |
| SCHEMBL30189641 | 0.63 | KCNH2 (0.33) | OPRK1 | |
| SCHEMBL7121073 | 0.63 | OPRL1 (0.35) | OPRK1 | |
| SCHEMBL9847781 | 0.62 | KDM4E (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194416-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2001-02-27 | — | — | US | disclosed |
| US-6187776-B1 | AZACYCLIC-SUBSTITUTED PYRIDINE DERIVATIVES; ALZHEIMER*S DISEASE, SCHIZOPHRENIA, GASTROINTESTINAL DISORDERS; COGNITION ACTIVATORS | ELI LILLY AND COMPANY | 2001-02-13 | — | — | US | disclosed |
| EP-0788489-A4 | HETEROCYCLIC COMPOUNDS AND THEIR USE | LILLY CO ELI (US) | 2000-11-15 | — | — | EP | disclosed |
| US-6071900-A | 2-AZABICYCLOOXYPYRIDAZINES TO TREAT DISEASES IN THE CENTRAL NERVOUS SYSTEM CAUSED BY MALFUNCTIONING OF THE MUSCARINIC CHOLINERGIC SYSTEM; ALZHEIMER'S DISEASE; ANALGESICS; GI AND SLEEPING DISORDERS; GLAUCOMA, PSYCHOSIS, ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 2000-06-06 | — | — | US | disclosed |
| US-6030966-A | FOR TREATING ALZEHIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998404-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5998434-A | Composition for treating pain | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0874828-A4 | COMPOSITION FOR TREATING PAIN | LILLY CO ELI (US) | 1999-09-01 | — | — | EP | disclosed |
| EP-0874828-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| EP-0788489-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE | ELI LILLY AND COMPANY (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1997020819-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1997-06-12 | — | — | WO | disclosed |
| EP-0773027-A1 | Use of azacyclic or azabicyclic pyrazine compounds for treating anxiety | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996012711-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE | ELI LILLY AND COMPANY (US) | 1996-05-02 | — | — | WO | disclosed |