Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121073 | 0.73 | OPRL1 (0.35) | — | |
| SCHEMBL30189641 | 0.73 | KCNH2 (0.33) | — | |
| SCHEMBL1843463 | 0.70 | ALDH1A1 (0.34) | — | |
| SCHEMBL633353 | 0.69 | SLC6A2 (0.43) | — | |
| SCHEMBL7898112 | 0.67 | OPRK1 (0.31) | — | |
| SCHEMBL7968110 | 0.66 | HTR6 (0.40) | CHRNB4CHRNA3 | |
| SCHEMBL29435414 | 0.66 | HTR6 (0.40) | CHRNB4CHRNA3 | |
| SCHEMBL27422130 | 0.65 | OPRM1 (0.34) | HSD11B1 | |
| SCHEMBL7458612 | 0.65 | OPRM1 (0.34) | HSD11B1 | |
| SCHEMBL8812050 | 0.64 | OPRM1 (0.36) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921860-A | Quinuclidyl- and tropanyl-pyridyl ethers as 5-HT3 receptor antagonists | JOHN WYETH AND BROTHER, LIMITED (GB) | 1990-05-01 | — | — | US | disclosed |