Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 15/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020233 | 0.83 | RAB9A (0.38) | HTR2A | |
| SCHEMBL5971560 | 0.72 | SLC6A4 (0.35) | — | |
| SCHEMBL8210476 | 0.65 | HTR2A (0.43) | HTR2AMAP2K4MAP2K7 | |
| SCHEMBL7121073 | 0.65 | OPRL1 (0.35) | — | |
| SCHEMBL10395740 | 0.64 | HTR2A (0.50) | HTR2AMAP2K4RBP4 | |
| SCHEMBL7898112 | 0.64 | OPRK1 (0.31) | — | |
| SCHEMBL633353 | 0.63 | SLC6A2 (0.43) | — | |
| SCHEMBL29435414 | 0.63 | HTR6 (0.40) | — | |
| SCHEMBL7968110 | 0.63 | HTR6 (0.40) | — | |
| SCHEMBL7973508 | 0.63 | HRH3 (0.38) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498331-B1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0498331-A1 | N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3.2.1)octanes, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-12 | — | — | EP | disclosed |