Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 8/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901346 | 0.90 | NR3C1 (0.50) | LIMK2LIMK1ALDH1A1PTGESNR3C1 | |
| SCHEMBL7715239 | 0.86 | LIMK2 (0.43) | LIMK2LIMK1ALDH1A1PTGESNR3C1 | |
| SCHEMBL7715230 | 0.84 | LIMK2 (0.56) | LIMK2LIMK1ALDH1A1PTGESMEN1 | |
| SCHEMBL7711039 | 0.79 | RAB9A (0.43) | LIMK2LIMK1ALDH1A1PTGESMEN1 | |
| SCHEMBL11067980 | 0.70 | HTT (0.73) | HTTALDH1A1MEN1KMT2A | |
| SCHEMBL10808044 | 0.69 | HTT (0.77) | HTTALDH1A1MEN1KMT2A | |
| SCHEMBL335974 | 0.69 | HTT (1.00) | HTTALDH1A1MEN1KMT2A | |
| SCHEMBL14194063 | 0.68 | HPGD (0.65) | HTTALDH1A1ARMEN1KMT2A | |
| SCHEMBL11067449 | 0.67 | HTT (0.63) | HTTALDH1A1ARMEN1KMT2A | |
| SCHEMBL11509515 | 0.66 | HTT (0.62) | HTTALDH1A1ARMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | disclosed |