Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 11/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TCF4 | P15884 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901346 | 0.86 | NR3C1 (0.50) | LIMK2LIMK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7898152 | 0.84 | HTT (0.51) | LIMK2LIMK1ALDH1A1MEN1KMT2A | |
| SCHEMBL7715239 | 0.83 | LIMK2 (0.43) | LIMK2LIMK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7711039 | 0.76 | RAB9A (0.43) | LIMK2LIMK1ALDH1A1LMNAMAPT | |
| SCHEMBL6959526 | 0.71 | TCF4 (0.75) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL11025715 | 0.71 | POLB (0.78) | ALDH1A1MAPTTCF4CTNNB1MEN1 | |
| SCHEMBL8269562 | 0.69 | TP53 (0.64) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL3562390 | 0.69 | POLB (0.62) | LIMK2LIMK1ALDH1A1TCF4CTNNB1 | |
| SCHEMBL17331309 | 0.68 | TCF4 (0.79) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL9001673 | 0.68 | TCF4 (0.59) | LIMK2LIMK1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | disclosed |