Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 7/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901346 | 0.88 | NR3C1 (0.50) | LIMK2LIMK1NR3C1ALDH1A1PTGES | |
| SCHEMBL7898152 | 0.86 | HTT (0.51) | LIMK2LIMK1NR3C1ALDH1A1PTGES | |
| SCHEMBL7715230 | 0.83 | LIMK2 (0.56) | LIMK2LIMK1ALDH1A1PTGESMEN1 | |
| SCHEMBL7711039 | 0.78 | RAB9A (0.43) | LIMK2LIMK1ALDH1A1PTGESMEN1 | |
| SCHEMBL5432947 | 0.69 | ALDH1A1 (0.67) | ALDH1A1CA2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14038512 | 0.69 | CA2 (0.51) | ALDH1A1CA2SMN1; SMN2 | |
| SCHEMBL19567186 | 0.68 | PTGS1 (0.63) | CA2MEN1KMT2ASMN1; SMN2PRMT6 | |
| SCHEMBL3523935 | 0.68 | POLB (0.57) | ALDH1A1CA2MEN1KMT2ALMNA | |
| SCHEMBL11853651 | 0.67 | CA2 (0.52) | ALDH1A1CA2SMN1; SMN2 | |
| SCHEMBL691809 | 0.66 | SMN1; SMN2 (0.59) | ALDH1A1CA2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | disclosed |