Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 7/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2813838 | 0.94 | KLK5 (0.36) | KLK5RENSCN9AACEHRH2 | |
| SCHEMBL7890024 | 0.94 | KLK5 (0.36) | KLK5RENSCN9AACEHRH2 | |
| SCHEMBL2813840 | 0.94 | KLK5 (0.36) | KLK5RENSCN9AACEHRH2 | |
| SCHEMBL2791623 | 0.92 | FPR2 (0.34) | RENCYP3A4ALDH1A1TSHRKMT2A | |
| SCHEMBL7899697 | 0.90 | PROKR1 (0.39) | CACNA1BKLK5SCN9AACEHRH2 | |
| SCHEMBL7902535 | 0.89 | USP30 (0.32) | KLK5RENSCN9ACYP3A4ALDH1A1 | |
| SCHEMBL7897503 | 0.89 | SCN9A (0.32) | KLK5RENSCN9AHRH2HRH1 | |
| SCHEMBL7901258 | 0.88 | PABPC1 (0.33) | KLK5HRH2HRH1 | |
| SCHEMBL2791534 | 0.88 | MMP13 (0.34) | KLK5CYP3A4ALDH1A1EEF2K | |
| SCHEMBL7897783 | 0.88 | PABPC1 (0.33) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |