Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955045 | 0.92 | MAPT (0.54) | SMN1; SMN2MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL7145528 | 0.86 | PRSS1 (0.48) | PRSS1CTSGCTRB1CMA1SMN1; SMN2 | |
| SCHEMBL2299009 | 0.85 | HPGD (0.59) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6160025 | 0.85 | MAPK1 (0.60) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL10630944 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL27371604 | 0.83 | ITGB3 (0.54) | PRSS1CTSGCTRB1CMA1SMN1; SMN2 | |
| SCHEMBL277398 | 0.83 | KDM4E (0.50) | PRSS1CTSGCTRB1CMA1SMN1; SMN2 | |
| SCHEMBL12497737 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL658648 | 0.81 | L3MBTL1 (0.69) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1KMT2A | |
| SCHEMBL2667533 | 0.81 | LMNA (0.56) | PRSS1CTSGCTRB1CMA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |