Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790839 | 0.83 | ADORA2A (0.49) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL10277681 | 0.82 | LRRK2 (0.47) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL789402 | 0.80 | CYP1A2 (0.41) | MAPTKDM4EALDH1A1L3MBTL1HPGD | |
| SCHEMBL9954672 | 0.71 | TDO2 (0.52) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL789847 | 0.69 | JAK2 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDADORA2A | |
| SCHEMBL14694267 | 0.68 | ADK (0.41) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9954881 | 0.67 | TDO2 (0.52) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1432961 | 0.67 | AKR1C3 (0.65) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL807328 | 0.65 | KDM4E (0.53) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31079126 | 0.64 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |