Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RRM1 | P23921 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7635242 | 0.98 | ACHE (0.39) | ACHEEPHX1ALOX15NAAADPP7 | |
| SCHEMBL7617282 | 0.81 | KDM5A (0.47) | ACHEEPHX1NAAADNM1ALDH1A1 | |
| SCHEMBL18074396 | 0.81 | KDM5A (0.47) | ACHEEPHX1NAAADNM1ALDH1A1 | |
| SCHEMBL7600192 | 0.80 | ALDH1A1 (0.42) | ALOX15NAAADNM1ALDH1A1 | |
| Butylamine SCHEMBL909929 | 0.79 | EPHX1 (0.48) | ACHEEPHX1ALOX15DPP7RRM1 | |
| Butane SCHEMBL28879542 | 0.78 | EPHX1 (0.56) | ACHEEPHX1ALOX15MMP2 | |
| SCHEMBL11146017 | 0.77 | DRD2 (0.49) | EPHX1ALOX15DNM1ALDH1A1 | |
| SCHEMBL20548058 | 0.77 | NAAA (0.47) | ACHEEPHX1NAAADNM1ALDH1A1 | |
| SCHEMBL2236238 | 0.77 | CA12 (0.37) | ACHEALDH1A1 | |
| SCHEMBL15542027 | 0.77 | CA12 (0.37) | ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474411-A1 | Production of diethanolamine derivatives and their intermediates | Takeda Chemical Industries, Ltd. (JP) | 1992-03-11 | — | — | EP | claimed |
| US-6190691-B1 | ADMINISTERING FORMULATION COMPRISING TUMOR NERCOSIS FACTOR (TNF) PRODUCTION-INHIBITORY AMOUNT OF A COMPOUND SELECTED FROM LOPERAMIDE AND DIPHENOXYLATE TO MAMMAL | ADOLOR CORPORATION | 2001-02-20 | — | — | US | disclosed |
| US-5962477-A | USING LOPERAMIDE | ADOLOR CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0937460-A2 | Use of an antidiarrheal for the manufacture of a medicament for the treatment of inflammatory conditions | Adolor Corporation (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0757558-A4 | SCREENING METHODS FOR INTEGUMENTAL INFLAMMATION MODULATING AGENTS | ALZA CORP (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0757558-A1 | SCREENING METHODS FOR INTEGUMENTAL INFLAMMATION MODULATING AGENTS | ALZA CORPORATION (US) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995027510-A1 | SCREENING METHODS FOR INTEGUMENTAL INFLAMMATION MODULATING AGENTS | ALZA CORPORATION (US) | 1995-10-19 | — | — | WO | disclosed |