Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892605 | 0.84 | BRD4 (0.35) | TNK2KMT2AADORA2AALDH1A1MAPT | |
| SCHEMBL7901581 | 0.77 | MAOA (0.37) | TNK2ALDH1A1HPGDMAPK1DHFR | |
| SCHEMBL31457290 | 0.74 | ALDH1A1 (0.45) | TNK2MEN1KMT2AFYNALDH1A1 | |
| SCHEMBL9173107 | 0.73 | DHFR (0.42) | TNK2ADORA2AALDH1A1MAPTKDM4E | |
| SCHEMBL11580822 | 0.68 | MAOB (0.48) | TNK2ALDH1A1MAPTGAAKDM4E | |
| SCHEMBL544598 | 0.68 | MAP4K4 (0.48) | TNK2MEN1KMT2AACHEALDH1A1 | |
| SCHEMBL9163459 | 0.68 | TTR (0.55) | TNK2KMT2AALDH1A1MAPTGAA | |
| SCHEMBL4700185 | 0.67 | TDO2 (0.55) | KMT2AFYNADORA1ADORA2AALDH1A1 | |
| SCHEMBL9172328 | 0.67 | FYN (0.40) | TNK2MEN1KMT2AFYNALDH1A1 | |
| SCHEMBL3289071 | 0.67 | AR (0.56) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197774-B1 | THERAPY FOR ASTHMA, SKIN DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-1019501-A1 | NOVEL PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998041526-A1 | NOVEL PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-24 | — | — | WO | disclosed |