Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328343 | 0.81 | PTH1R (0.48) | PTH1R | |
| SCHEMBL7902547 | 0.74 | OPRL1 (0.56) | OPRL1OPRM1OPRK1CHRM3CHRM2 | |
| SCHEMBL15847630 | 0.74 | DRD2 (0.68) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL5324889 | 0.73 | OPRL1 (0.46) | OPRL1OPRM1OPRK1CHRM3CHRM2 | |
| SCHEMBL250673 | 0.71 | ACHE (0.69) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL7447387 | 0.69 | OPRL1 (0.69) | OPRL1OPRM1OPRK1CHRM3CHRM2 | |
| SCHEMBL1861204 | 0.69 | OPRM1 (0.55) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL1861203 | 0.69 | OPRM1 (0.55) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL13016528 | 0.68 | ACHE (0.67) | OPRL1OPRM1OPRK1CHRM3CHRM2 | |
| SCHEMBL3075361 | 0.67 | OPRL1 (0.66) | OPRL1OPRM1OPRK1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |