Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902988 | 0.89 | GRIN1 (0.32) | NPC1RAB9ASMN1; SMN2AXL | |
| SCHEMBL7913253 | 0.87 | MAOB (0.34) | SMN1; SMN2IKBKESTK4STK3LRRK2 | |
| SCHEMBL7902852 | 0.86 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2STK4STK3 | |
| SCHEMBL7902845 | 0.85 | PIM1 (0.31) | — | |
| SCHEMBL7920535 | 0.84 | DHFR (0.33) | DHFRIKBKESTK4STK3LRRK2 | |
| SCHEMBL7914652 | 0.84 | DYRK3 (0.37) | RAB9A | |
| SCHEMBL7929296 | 0.81 | DYRK3 (0.49) | SMN1; SMN2 | |
| SCHEMBL7916997 | 0.81 | JAK2 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7911686 | 0.78 | PGR (0.34) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7910125 | 0.78 | PGR (0.34) | NPC1RAB9ASMN1; SMN2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |