Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 7/20 | 0.38 |
| ▸ | MMP3 | P08254 | 7/20 | 0.38 |
| ▸ | MMP8 | P22894 | 7/20 | 0.38 |
| ▸ | MMP13 | P45452 | 7/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904000 | 1.00 | MMP1 (0.38) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL6485131 | 0.81 | METAP2 (0.53) | METAP2METAP1DPP4 | |
| SCHEMBL6483321 | 0.81 | METAP2 (0.53) | METAP2METAP1DPP4 | |
| SCHEMBL21206315 | 0.70 | CPB2 (0.42) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7229428 | 0.70 | SLC1A3 (0.42) | METAP2METAP1 | |
| SCHEMBL5980910 | 0.70 | SLC1A3 (0.42) | METAP2METAP1 | |
| SCHEMBL5981288 | 0.70 | SLC1A3 (0.42) | METAP2METAP1 | |
| SCHEMBL2164847 | 0.70 | SLC1A3 (0.42) | METAP2METAP1 | |
| SCHEMBL2164841 | 0.70 | SLC1A3 (0.42) | METAP2METAP1 | |
| SCHEMBL6627499 | 0.69 | CTSK (0.58) | CTSKMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |