Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792636 | 0.92 | CCNK (0.44) | CCNKCDK12TRPV3HPGDSJAK2 | |
| SCHEMBL7901095 | 0.80 | HPGDS (0.46) | TRPV3HPGDSJAK2JAK1KDM4E | |
| SCHEMBL2792693 | 0.78 | GPR119 (0.46) | TRPV3HPGDSJAK2JAK1KDM4E | |
| SCHEMBL2789436 | 0.77 | HPGDS (0.51) | CCNKCDK12HPGDSJAK2JAK1 | |
| SCHEMBL7899970 | 0.77 | HPGDS (0.51) | CCNKCDK12HPGDSJAK2JAK1 | |
| SCHEMBL15650585 | 0.76 | PDE4B (0.53) | TRPV3HPGDSJAK2JAK1MAPT | |
| SCHEMBL16040307 | 0.76 | CDK12 (0.60) | CCNKCDK12HPGDSJAK2JAK1 | |
| SCHEMBL16042797 | 0.76 | CCNK (0.64) | CCNKCDK12CCNT1CDK9 | |
| SCHEMBL16040287 | 0.76 | CDK9 (0.68) | CCNKCDK12CCNT1CDK9 | |
| SCHEMBL2791157 | 0.74 | TRPV3 (0.43) | TRPV3HPGDSJAK2JAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |