Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ATP4A | P20648 | 6/20 | 0.37 |
| ▸ | ATP4B | P51164 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903994 | 0.94 | ATP4A (0.40) | ATP4AATP4B | |
| SCHEMBL7896441 | 0.91 | HTR1B (0.37) | ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7903914 | 0.90 | HTR1B (0.36) | ALDH1A1KDM4E | |
| SCHEMBL7902622 | 0.89 | KDM4E (0.36) | ALDH1A1KDM4E | |
| SCHEMBL7905806 | 0.88 | HTR7 (0.40) | ALDH1A1DRD2KDM4E | |
| SCHEMBL7896514 | 0.83 | HRH3 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL7903964 | 0.82 | HTR1B (0.34) | ALDH1A1KDM4E | |
| SCHEMBL7904681 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KDM4E | |
| SCHEMBL7904663 | 0.81 | MEN1 (0.35) | ALDH1A1DRD2DRD3KDM4E | |
| SCHEMBL7896411 | 0.81 | USP2 (0.43) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |