Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM1A | O60341 | 4/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668412 | 0.78 | HSP90AA1 (0.50) | RAB9ANPC1SMN1; SMN2KDM1AMETAP2 | |
| SCHEMBL7904670 | 0.75 | KDM1A (0.39) | RAB9ANPC1SMN1; SMN2KDM1AHPGD | |
| SCHEMBL9864721 | 0.74 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2METAP2HSD17B10 | |
| SCHEMBL7903987 | 0.74 | KDM1A (0.40) | RAB9AKDM1AHSD17B10TSHR | |
| SCHEMBL7896420 | 0.74 | KDM1A (0.40) | KDM1A | |
| SCHEMBL10557053 | 0.72 | SMN1; SMN2 (0.53) | RAB9ANPC1SMN1; SMN2KDM1AMETAP2 | |
| SCHEMBL9046223 | 0.66 | NR1H2 (0.47) | TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL10559699 | 0.66 | METAP2 (0.52) | RAB9ANPC1KDM1AMETAP2HSD17B10 | |
| SCHEMBL13752162 | 0.65 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2METAP2HSD17B10 | |
| SCHEMBL7840644 | 0.64 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2KDM1AMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |