Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18325610 | 0.87 | XDH (0.50) | — | |
| SCHEMBL18325670 | 0.87 | XDH (0.39) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL7052872 | 0.81 | ADORA2A (0.44) | — | |
| SCHEMBL12104083 | 0.74 | HDAC1 (0.43) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL1225985 | 0.72 | GDA (0.36) | — | |
| SCHEMBL31635252 | 0.69 | HDAC1 (0.62) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL15480424 | 0.68 | HDAC1 (0.64) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL15480418 | 0.68 | HDAC1 (0.56) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL15480421 | 0.68 | HDAC1 (0.59) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL21184198 | 0.68 | CYP3A4 (0.71) | HDAC1HDAC2HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46144-E1 | Hydroxamic acid derivatives | PURDUE PHARMACEUTICAL PRODUCTS L.P. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9096627-B2 | Hydroxamic acid derivatives | PURDUE PHARMACEUTICAL PRODUCTS L.P. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140066419-A1 | HYDROXAMIC ACID DERIVATIVES | PURDUE PHARMACEUTICAL PRODUCTS L.P. (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110269706-A1 | Hydroxamic Acid Derivatives | NORTHLAKE BIOSCIENCES LLC (US) | 2011-11-03 | — | — | US | disclosed |
| WO-2010085377-A2 | HYDROXAMIC ACID DERIVATIVES | CRYSTAL BIOPHARMACEUTICAL LLC (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066419-A1 | HYDROXAMIC ACID DERIVATIVES | HDAC5, HDAC7, HDAC4 | HDAC1 4/4885HDAC2 8/4885HDAC6 7/4885 |
| US-20110269706-A1 | Hydroxamic Acid Derivatives | CD74, HLA-DRB1, HDAC5 | HDAC1 7/4885HDAC2 15/4885HDAC6 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.