Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10674706 | 0.78 | MDM4 (0.50) | MDM4TP53CETPMDM2TDP1 | |
| SCHEMBL9706115 | 0.78 | MAPT (0.41) | TP53POLBTDP1KDM4EALDH1A1 | |
| SCHEMBL5720958 | 0.78 | L3MBTL1 (0.44) | ALDH1A1 | |
| SCHEMBL4131268 | 0.78 | L3MBTL1 (0.44) | ALDH1A1 | |
| SCHEMBL28986402 | 0.74 | MDM4 (0.52) | MDM4TP53CETPMDM2TDP1 | |
| SCHEMBL11316811 | 0.71 | TDP1 (0.58) | TDP1KDM4EALDH1A1 | |
| SCHEMBL4143294 | 0.71 | TDP1 (0.35) | TDP1KDM4EALDH1A1 | |
| SCHEMBL25465973 | 0.69 | P2RX7 (0.34) | TDP1KDM4EALDH1A1ADRA2AADRA2B | |
| SCHEMBL3879540 | 0.69 | TRPA1 (0.41) | TP53TDP1KDM4EALDH1A1 | |
| SCHEMBL2103261 | 0.68 | GPR35 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60146884-A | — | — | None | — | — | JP | disclosed |
| US-6197953-B1 | ESTER INTERCHANGE, CRYSTALLIZATION, ISOMERIZATION; PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES | TANABE SEIYAKU CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| US-5998637-A | CRYSTALLIZATION; SEPARATION | TANABE SEIYAKU CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0861834-A1 | Process for preparing optically active trans-3-substituted glycidic acid ester | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-4654335-A | CARDIOVASCULAR AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0208964-A2 | 1,5-Benzothiazepine compounds | E.R. Squibb & Sons, Inc. (US) | 1987-01-21 | — | — | EP | disclosed |
| JP-S60146884-A | PRODUCTION OF 1,5-BENZOTHIAZEPINE DERIVATIVE | NIPPON CHEM:KK | 1985-08-02 | — | — | JP | disclosed |