SCHEMBL7906774

SCHEMBL7906774

Cn1nc(-c2ncc(Cl)cc2F)c(N)c1OC(F)F

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.33
LTA4H P09960 1/20 0.33
FPR2 P25090 2/20 0.32
PROKR1 Q8TCW9 2/20 0.32
CHRM4 P08173 1/20 0.32
RXRA P19793 5/20 0.32
GRIN1 Q05586 5/20 0.32
GRIN2B Q13224 5/20 0.32
BACE1 P56817 6/20 0.31
PDE2A O00408 1/20 0.31
SCN9A Q15858 1/20 0.31
SLC34A1 Q06495 1/20 0.31
REN P00797 2/20 0.31
CTSD P07339 2/20 0.31
BACE2 Q9Y5Z0 2/20 0.31
MET P08581 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7684500 0.87 SLC34A1 (0.34) FPR2PROKR1RXRAGRIN1GRIN2B
SCHEMBL7691034 0.85 FPR2 (0.32) FPR2PROKR1PDE2ASLC34A1
SCHEMBL7904399 0.85 FPR2 (0.32) FPR2PROKR1PDE2ASLC34A1
SCHEMBL7689593 0.82 SMN1; SMN2 (0.38) FPR2PROKR1PDE2A
SCHEMBL7898138 0.80 MAPT (0.35) FPR2PROKR1SLC34A1
SCHEMBL7691222 0.77 SLC34A1 (0.32) RXRAGRIN1GRIN2BPDE2ASLC34A1
SCHEMBL7691458 0.74 FPR2 (0.33) KCNH2FPR2PROKR1RXRAGRIN1
SCHEMBL7907722 0.72 FPR2 (0.33) FPR2PROKR1PDE2A
SCHEMBL7683489 0.70 SCN9A (0.33) SCN9ASLC34A1
SCHEMBL6295365 0.69 HSD11B1 (0.36) FPR2PROKR1PDE2ASCN9ASLC34A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6204221-B1 Herbicides SYNGENTA CROP PROTECTION, INC. 2001-03-20 US disclosed
CN-1237166-A Pyrazole derivatives useful as herbicides NOVARTIS AG (CH) 1999-12-01 CN disclosed
EP-0941222-A2 PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES Novartis AG (CH) 1999-09-15 EP disclosed
WO-1998021199-A2 PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES NOVARTIS AG (CH) 1998-05-22 WO disclosed