Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585669 | 0.83 | CYP19A1 (0.43) | RPS6KB1GSK3BCYP19A1ALDH1A1 | |
| SCHEMBL15800184 | 0.81 | HSD17B10 (0.34) | CYP19A1 | |
| SCHEMBL18754827 | 0.79 | CYP19A1 (0.36) | RPS6KB1GSK3BCYP19A1ALDH1A1 | |
| SCHEMBL584717 | 0.76 | ALDH1A1 (0.33) | RPS6KB1GSK3BALDH1A1 | |
| SCHEMBL24880321 | 0.73 | PDE10A (0.36) | CYP19A1 | |
| SCHEMBL1435520 | 0.73 | CYP19A1 (0.41) | CYP19A1ALDH1A1 | |
| SCHEMBL27867261 | 0.71 | CYP19A1 (0.40) | CYP19A1 | |
| SCHEMBL27850120 | 0.71 | CYP19A1 (0.45) | RPS6KB1GSK3BCYP19A1ALDH1A1 | |
| SCHEMBL3868934 | 0.67 | SPNS2 (0.49) | ALDH1A1 | |
| SCHEMBL9645498 | 0.67 | CYP19A1 (0.45) | CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754100-B2 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-06-17 | — | — | US | disclosed |
| EP-2615090-A1 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2013-07-17 | — | — | EP | disclosed |
| EP-2401276-B1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2010098487-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |