Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994597 | 0.87 | LMNA (0.43) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7977065 | 0.84 | LMNA (0.51) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7991272 | 0.83 | LMNA (0.50) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7994711 | 0.83 | RAB9A (0.49) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7977309 | 0.77 | PDE4A (0.52) | LMNAPDE4A | |
| SCHEMBL14691446 | 0.77 | TTR (0.51) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7987426 | 0.76 | PDE4A (0.65) | PDE4A | |
| SCHEMBL7996011 | 0.74 | LMNA (0.41) | LMNAPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4536330 | 0.74 | MAPK1 (0.56) | LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL7908376 | 0.74 | PDE4A (0.44) | PDE4BPDE4DPDE4APDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |