Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906619 | 0.91 | ITGB3 (0.47) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL8380840 | 0.90 | ITGB3 (0.46) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL8380937 | 0.89 | ITGB3 (0.46) | ITGB3ITGA2BTMPRSS2HTTMEN1 | |
| SCHEMBL7906618 | 0.88 | HTT (0.49) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL7907917 | 0.85 | MEN1 (0.52) | TMPRSS2ALDH1A1TP53MEN1KMT2A | |
| SCHEMBL7900135 | 0.85 | ITGB3 (0.48) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL7913438 | 0.85 | GAA (0.43) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL8384345 | 0.83 | ITGB3 (0.40) | ITGB3ITGA2BTMPRSS2HTTNAMPT | |
| SCHEMBL7900146 | 0.83 | ITGB3 (0.42) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL8386290 | 0.82 | ITGB3 (0.42) | ITGB3ITGA2BHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |