Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 7/20 | 0.40 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900135 | 0.95 | ITGB3 (0.48) | ITGB3ITGA2BTMPRSS2F2F10 | |
| SCHEMBL8386175 | 0.85 | CA12 (0.41) | ITGB3ITGA2BTMPRSS2F2F10 | |
| SCHEMBL7906618 | 0.84 | HTT (0.49) | ITGB3ITGA2BTMPRSS2F2F10 | |
| SCHEMBL7907920 | 0.83 | ITGB3 (0.53) | ITGB3ITGA2BTMPRSS2F2F10 | |
| SCHEMBL7909741 | 0.82 | F10 (0.41) | ITGB3ITGA2BF10HTTALDH1A1 | |
| SCHEMBL7906619 | 0.81 | ITGB3 (0.47) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL8380937 | 0.80 | ITGB3 (0.46) | ITGB3ITGA2BTMPRSS2F2F10 | |
| SCHEMBL8386550 | 0.79 | CASP1 (0.41) | ITGB3ITGA2BF2F10ALDH1A1 | |
| SCHEMBL8380840 | 0.79 | ITGB3 (0.46) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 | |
| SCHEMBL7913438 | 0.78 | GAA (0.43) | ITGB3ITGA2BTMPRSS2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |