Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976947 | 0.80 | PDE4A (0.39) | PDE4AKCNH2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL7908336 | 0.80 | PDE4A (0.38) | PDE4AKCNH2FBP1PDE4BPDE4C | |
| SCHEMBL7991148 | 0.79 | PDE4A (0.34) | PDE4AFBP1PDE4BPDE4CPDE4D | |
| SCHEMBL7978041 | 0.79 | PDE4A (0.53) | PDE4AKCNH2 | |
| SCHEMBL7992704 | 0.78 | F7 (0.36) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7996011 | 0.77 | LMNA (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7991436 | 0.77 | PDE4A (0.38) | PDE4AKCNH2PDE4D | |
| SCHEMBL7990957 | 0.77 | RAB9A (0.39) | PDE4AFBP1PDE4BPDE4CPDE4D | |
| SCHEMBL7994826 | 0.75 | PDE4B (0.33) | PDE4AFBP1PDE4BPDE4CPDE4D | |
| SCHEMBL7904298 | 0.72 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |