Sugi Predict

Sugi Predict / Compounds / SCHEMBL7909433

SCHEMBL7909433

SCHEMBL7909433

CC1CCC(=O)N(c2ccccc2)C1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.54
▸ USP2 O75604 2/20 0.54
▸ POLB P06746 2/20 0.54
▸ MAPT P10636 1/20 0.54
▸ HPGD P15428 1/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.54
▸ MT-CO2 P00403 1/20 0.44
▸ ALOX5 P09917 1/20 0.44
▸ DDB1 Q16531 1/20 0.44
▸ CRBN Q96SW2 1/20 0.44
▸ SRD5A1 P18405 1/20 0.44
▸ NPC1 O15118 2/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ G6PD P11413 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ AKR1C3 P42330 1/20 0.42
▸ PDE4A P27815 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16474469 1.00 ALDH1A1 (0.54) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL16474467 1.00 ALDH1A1 (0.54) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL19998591 0.81 POLB (0.57) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL435086 0.81 POLB (0.57) ALDH1A1USP2POLBMAPTHPGD
Methyl Alcohol SCHEMBL28445158 0.79 POLB (0.54) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL14171699 0.76 ALDH1A1 (0.41) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL18379593 0.75 ALDH1A1 (0.46) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL14275855 0.72 ALDH1A1 (0.44) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL609915 0.70 NOTUM (0.42) ALDH1A1USP2POLBMAPTHPGD
SCHEMBL14275864 0.70 RAB9A (0.46) ALDH1A1USP2POLBMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2903991-B1 ANTI-FIBROTIC PYRIDINONES INTERMUNE INC (US) 2020-09-16 — — EP disclosed
US-10544161-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2020-01-28 — — US disclosed
US-20190321343-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2019-10-24 — — US disclosed
US-10376497-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2019-08-13 — — US disclosed
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2019-05-16 — — US disclosed
US-10233195-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2019-03-19 — — US disclosed
US-20180064692-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2018-03-08 — — US disclosed
US-20180064692-A1 Anti-Fibrotic Pyridinones GENENTECH, INC. 2018-03-08 — — US disclosed
US-9675593-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2017-06-13 — — US disclosed
US-9675593-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2017-06-13 — — US disclosed
US-20170121345-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2017-05-04 — — US disclosed
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2016-09-15 — — US disclosed
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2016-09-15 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
WO-2015153683-A1 ANTI-FIBROTIC PYRIDINONES INTERMUNE, INC. (US) 2015-10-08 — — WO disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed
US-6200718-B1 A POLYMERIZED TONER OF CORE-SHELL STRUCTURE, COMPRISING CORE PARTICLES COMPOSED OF COLORED POLYMER PARTICLES WHICH CONTAIN A COMPOUND HAVING >C=N+ STRUCTURE IN ITS MOLECULE AND A COLORANT AND A LAYER OF POLYMER COVERING CORE PARTICLES NIPPON ZEON CO., LTD. (JP) 2001-03-13 — — US disclosed
EP-0947888-A1 POLYMER TONER AND METHOD OF PRODUCTION THEREOF NIPPON ZEON CO., LTD. (JP) 1999-10-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180064692-A1 Anti-Fibrotic Pyridinones MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-10544161-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-20190321343-A1 Anti-Fibrotic Pyridinones MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-10233195-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-10376497-B2 Anti-fibrotic pyridinones MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-20170121345-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885
US-20190144467-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 ALDH1A1 529/4885USP2 2249/4885POLB 1266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.