Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.51 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906625 | 0.84 | LMNA (0.46) | ITGB3ITGA2LMNAPAX8GAA | |
| SCHEMBL7909845 | 0.82 | ITGB3 (0.56) | ITGB3ITGA2BITGA2CHRM3GAA | |
| Hydrochloric Acid SCHEMBL7909753 | 0.81 | POLB (0.57) | ITGB3ITGA2BITGA2CHRM3GAA | |
| SCHEMBL7909438 | 0.80 | ITGB3 (0.54) | ITGB3ITGA2BITGA2LMNACHRM3 | |
| SCHEMBL7909440 | 0.79 | ITGB3 (0.54) | ITGB3ITGA2BITGA2LMNACHRM3 | |
| SCHEMBL7900157 | 0.78 | ITGB3 (0.51) | ITGB3ITGA2BITGA2CHRM3GAA | |
| SCHEMBL8386242 | 0.76 | EPHX2 (0.54) | ITGB3ITGA2BITGA2LMNAPAX8 | |
| SCHEMBL8508634 | 0.75 | SIGMAR1 (0.59) | ITGB3ITGA2BCHRM3OPRD1 | |
| SCHEMBL7909451 | 0.74 | ITGB3 (0.53) | ITGB3ITGA2BITGA2CHRM3GAA | |
| SCHEMBL9335419 | 0.73 | ITGB3 (0.74) | ITGB3ITGA2BITGA2GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| CN-1056141-C | Piperazine derivatives | MERCK PATENT GESELLSCHAFTR MIT (DE) | 2000-09-06 | — | — | CN | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| CN-1099759-A | Piperazine derivatives | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | CN | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |