Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509166 | 0.82 | CRBN (0.36) | MT-CO2SIRT2SIRT1SRD5A1 | |
| SCHEMBL2529611 | 0.78 | MT-CO2 (0.42) | MT-CO2CA12CA1CA2CA9 | |
| SCHEMBL31715318 | 0.77 | ALDH1A1 (0.47) | HDAC1HDAC6KMT2ALMNAALDH1A1 | |
| SCHEMBL300884 | 0.76 | CA12 (0.42) | CA12CA1CA2CA9CA14 | |
| SCHEMBL5766183 | 0.75 | MAPT (0.42) | MT-CO2CA12CA1CA2CA9 | |
| SCHEMBL2309862 | 0.75 | LMNA (0.51) | CA12CA1CA2CA9CA14 | |
| SCHEMBL8117544 | 0.75 | POLB (0.37) | MT-CO2 | |
| SCHEMBL13498680 | 0.74 | ALDH1A1 (0.46) | CA12CA1CA9KMT2AALDH1A1 | |
| SCHEMBL12085974 | 0.74 | KMT2A (0.39) | CA1CA2KMT2ALMNAALDH1A1 | |
| SCHEMBL7273843 | 0.74 | SMN1; SMN2 (0.48) | CA1CA2HDAC1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3027356-A | — | — | None | — | — | JP | disclosed |
| US-6217845-B1 | IMAGING; THERAPY | ANORMED, INC. (CA) | 2001-04-17 | — | — | US | disclosed |
| US-5753520-A | BIOCHEMICAL CONJUGATED WITH A HYDRAZINE OR A HYDRAZONE COMPOUND AS DRUG DELIVERY; HIGH BIOLOGICAL SPECIFICITY; MEDICINE FOR IMAGING, THERAPY, RADIOACTIVE TAGGING | JOHNSON MATTHEY INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0384769-B1 | Protein labelling | JOHNSON MATTHEY PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| US-5420285-A | Imaging for medicine | JOHNSON MATTHEY, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5206370-A | Certain pyridyl hydrazines and hydrazides useful for protein labeling | JOHNSON MATTHEY, INC. (US) | 1993-04-27 | — | — | US | disclosed |
| JP-H0327356-A | LABELING OF PROTEIN | JOHNSON MATTHEY INC | 1991-02-05 | — | — | JP | disclosed |
| EP-0384769-A2 | Protein labelling | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1990-08-29 | — | — | EP | disclosed |