Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509476 | 0.85 | HTR5A (0.43) | SLC9A1HDAC1HTR5A | |
| SCHEMBL16509458 | 0.78 | SLC22A12 (0.44) | PLAUHDAC1TRPV1KDM4EMAPT | |
| SCHEMBL7913890 | 0.78 | KDM4E (0.38) | F2PLGPLAUPLATKLK1 | |
| SCHEMBL7920242 | 0.77 | ALOX15 (0.49) | PLAUPDE4BF10HDAC1TRPV1 | |
| SCHEMBL16502816 | 0.71 | HTR5A (0.51) | SLC9A1HTR5A | |
| SCHEMBL7919099 | 0.71 | HTR5A (0.36) | SLC9A1KDM4EHTR5AGRM4 | |
| SCHEMBL16503540 | 0.71 | HTR5A (0.36) | SLC9A1KDM4EHTR5AGRM4 | |
| SCHEMBL7918359 | 0.70 | SLC9A1 (0.44) | PLAUSLC9A1HTR5A | |
| SCHEMBL9909261 | 0.69 | HTR5A (0.49) | PLAUSLC9A1F10KDM4EMAPT | |
| SCHEMBL7915993 | 0.69 | SLC9A1 (0.48) | SLC9A1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |