Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509458 | 0.88 | SLC22A12 (0.44) | KDM4EMAPTMAPK1KMT2AHDAC1 | |
| SCHEMBL7906709 | 0.82 | CA1 (0.41) | KDM4EMAPTMAPK1KMT2AESR2 | |
| SCHEMBL7920242 | 0.81 | ALOX15 (0.49) | KDM4EMAPTMAPK1PDE4BHDAC1 | |
| SCHEMBL16503471 | 0.81 | DOT1L (0.39) | KDM4EMAPTTRPV1ESR1ESR2 | |
| SCHEMBL7917427 | 0.81 | F2 (0.41) | KDM4EMAPTMAPK1KMT2AESR1 | |
| SCHEMBL16509476 | 0.80 | HTR5A (0.43) | HDAC1CYP2C9CYP2C19 | |
| SCHEMBL7911041 | 0.78 | F2 (0.35) | KDM4EMAPTMAPK1KMT2APDE4B | |
| SCHEMBL7920176 | 0.77 | CCR1 (0.46) | KDM4EMAPTHDAC1HTTF2 | |
| SCHEMBL7918689 | 0.74 | KDM4E (0.45) | KDM4EMAPTMAPK1KMT2AHTT | |
| SCHEMBL16503580 | 0.71 | XDH (0.38) | KDM4EMAPTMAPK1SLC22A12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |