Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.51 |
| ▸ | LTA4H | P09960 | 6/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911137 | 0.90 | ALDH1A1 (0.53) | MTNR1AMTNR1BMAOAMAOBTRPM8 | |
| SCHEMBL7900907 | 0.88 | PTGS1 (0.54) | MTNR1AMTNR1BLTA4HPLA2G2ACDK2 | |
| SCHEMBL7907433 | 0.83 | FFAR4 (0.57) | MAOAMAOBKMT2AMEN1KDM4E | |
| SCHEMBL7908891 | 0.80 | FFAR4 (0.56) | MTNR1AMTNR1BMAOBKMT2AMEN1 | |
| SCHEMBL3962253 | 0.79 | MAOB (0.61) | MAOBKMT2AMEN1KDM4ELMNA | |
| SCHEMBL6516526 | 0.79 | GPR84 (0.61) | CDK2KMT2APOLBMEN1MAPT | |
| SCHEMBL7901066 | 0.79 | MAOB (0.54) | MTNR1AMTNR1BMAOBKMT2AMEN1 | |
| SCHEMBL22438767 | 0.79 | MET (0.52) | MTNR1AMAOBPLA2G2AKMT2AMEN1 | |
| SCHEMBL4566997 | 0.79 | MAOB (0.51) | MAOBPLA2G2AMAPTKDM4ELMNA | |
| SCHEMBL21924287 | 0.77 | MAOB (0.58) | MAOBKMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |