Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386948 | 0.86 | KMT2A (0.40) | KMT2ATPSAB1TPSD1TPSG1POLB | |
| SCHEMBL7913360 | 0.82 | TPSAB1 (0.37) | ITGB3ITGA2BKMT2AGLAHTR1A | |
| SCHEMBL16574883 | 0.81 | ITGB3 (0.48) | ITGB3ITGA2BKDM1AGLAHTR1A | |
| SCHEMBL8473161 | 0.79 | CA2 (0.50) | KMT2ATPSAB1TPSD1TPSG1POLB | |
| SCHEMBL7528972 | 0.77 | GLA (0.53) | ITGB3ITGA2BKMT2AGLAPOLB | |
| Aziridine SCHEMBL28507214 | 0.76 | GLA (0.57) | ITGB3ITGA2BKDM1AGLAHTR1A | |
| SCHEMBL16574879 | 0.75 | ITGB3 (0.44) | ITGB3ITGA2BKMT2AGLAHTR1A | |
| SCHEMBL7344790 | 0.75 | GLA (0.55) | ITGB3ITGA2BKMT2AGLAPOLB | |
| SCHEMBL905223 | 0.75 | GLA (0.55) | ITGB3ITGA2BKMT2AGLAPOLB | |
| SCHEMBL13387648 | 0.73 | TPSAB1 (0.42) | KMT2ATPSAB1TPSD1TPSG1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |