Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386026 | 0.86 | ITGB3 (0.40) | TPSAB1TPSD1TPSG1KMT2AITGB3 | |
| SCHEMBL7909740 | 0.86 | SMN1; SMN2 (0.46) | TPSAB1TPSD1TPSG1KMT2AGLA | |
| SCHEMBL7913442 | 0.82 | ITGB3 (0.43) | TPSAB1TPSD1TPSG1KMT2AGLA | |
| SCHEMBL8384455 | 0.81 | PKM (0.45) | TPSAB1TPSD1TPSG1GLAHTR1A | |
| SCHEMBL8382720 | 0.79 | KMT2A (0.48) | TPSAB1TPSD1TPSG1KMT2AITGB3 | |
| SCHEMBL8381872 | 0.77 | PKM (0.40) | TPSAB1TPSD1TPSG1KMT2AITGB3 | |
| SCHEMBL8384378 | 0.73 | MAPK1 (0.47) | HTR1AHTR7ITGB3ITGA2BMAPK1 | |
| SCHEMBL18596470 | 0.71 | TDP1 (0.56) | KMT2AMAPK1KDM4EDRD2DRD3 | |
| SCHEMBL657440 | 0.70 | POLB (0.59) | KMT2AGLAHTR1AHTR7ITGB3 | |
| SCHEMBL7909434 | 0.69 | SMN1; SMN2 (0.50) | TPSAB1TPSD1TPSG1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |