Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29556839 | 0.88 | ALPL (0.56) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL790824 | 0.88 | ALPL (0.56) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL789981 | 0.86 | ALPL (0.48) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL17946272 | 0.85 | ALPL (0.42) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL9955288 | 0.82 | PIK3CG (0.52) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL790432 | 0.82 | PIK3CA (0.45) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL3115744 | 0.81 | PIK3CD (0.57) | PIK3CGPIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL29555684 | 0.81 | PIK3CD (0.57) | PIK3CGPIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL22447743 | 0.81 | ALPL (0.45) | ALPLPIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL791191 | 0.81 | PDGFRB (0.44) | ALPLPIK3CGPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |