Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorthiamid SCHEMBL54987 | 0.86 | ALDH1A1 (0.50) | GAAALDH1A1L3MBTL1TAAR1 | |
| Chlorthiamid SCHEMBL8541243 | 0.86 | ALDH1A1 (0.50) | GAAALDH1A1L3MBTL1TAAR1 | |
| SCHEMBL318849 | 0.86 | CES2 (0.50) | ITGB2ICAM1ITGALCES2CES1 | |
| SCHEMBL20560200 | 0.83 | GAA (0.47) | GAAALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL2867748 | 0.81 | PBRM1 (0.58) | GAAITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL4737570 | 0.81 | BACE1 (0.50) | GAAITGB2ICAM1ITGALALDH1A1 | |
| Hydrochloric Acid SCHEMBL15568289 | 0.79 | PBRM1 (0.56) | GAAITGB2ICAM1ITGALALDH1A1 | |
| Hydrochloric Acid SCHEMBL3717023 | 0.79 | BACE1 (0.49) | GAAITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL11825893 | 0.78 | TSHR (0.46) | ALDH1A1L3MBTL1JAK1 | |
| SCHEMBL7242129 | 0.78 | PBRM1 (0.44) | GAAITGB2ICAM1ITGALALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140171408-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-8697708-B2 | Azabenzothiazole compounds, compositions and methods of use | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-15 | — | — | US | disclosed |
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| CN-103209695-A | Azabenzothiazole compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2013-07-17 | — | — | CN | disclosed |
| US-20120202788-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-09 | — | — | US | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |
| EP-1123291-B1 | PROCESS FOR PREPARING 3-(SUBSTITUTED PHENYL)-5-THIENYL OR FURYL)-1,2,4-TRIAZOLES AND NOVEL INTERMEDIATES UTILIZED THEREIN | DOW AGROSCIENCES LLC (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1123291-B1 | PROCESS FOR PREPARING 3-(SUBSTITUTED PHENYL)-5-THIENYL OR FURYL)-1,2,4-TRIAZOLES AND NOVEL INTERMEDIATES UTILIZED THEREIN | DOW AGROSCIENCES LLC (US) | 2007-07-18 | — | — | EP | disclosed |
| CN-1136218-C | Process for preparing 3- (substituted phenyl) -5- (thienyl or furyl) -1, 2, 4-triazoles and novel intermediates used therein | ��ũҵ��ѧ��˾ | 2004-01-28 | — | — | CN | disclosed |
| CN-1124274-C | 3- (substituted phenyl) -5-thienyl-1, 2, 4-triazole compounds for controlling whitefly | DOW AGROSCIENCES LLC (US) | 2003-10-15 | — | — | CN | disclosed |
| US-6329528-B1 | REACTING ALKYL BENZTHIOIMIDATE OR ITS ACID ADDITION SALT WITH FURAN OR THIOFURAN ACID CHLORIDE COMPOUND TO PRODUCT ADDUCT-INTERMEDIATE; REACTING WITH METHYLHYDRAZINE TO PRODUCE 3-(SUBSTITUTED PHENYL)-5-THIENYL OR FURYL)-1,2,4-TRIAZOLES | DOW AGROSCIENCES LLC | 2001-12-11 | — | — | US | disclosed |
| CN-1324357-A | 3- (substituted phenyl) -5-thienyl-1, 2, 4-triazole compounds for controlling whitefly | DOW AGROSCIENCES LLC (US) | 2001-11-28 | — | — | CN | disclosed |
| CN-1324356-A | Process for preparing 3- (substituted phenyl) -5- (thienyl or furyl) -1, 2, 4-triazoles and novel intermediates used therein | DOW AGROSCIENCES CORP (US) | 2001-11-28 | — | — | CN | disclosed |
| EP-1123291-A1 | PROCESS FOR PREPARING 3-(SUBSTITUTED PHENYL)-5-THIENYL OR FURYL)-1,2,4-TRIAZOLES AND NOVEL INTERMEDIATES UTILIZED THEREIN | Dow Agrosciences LLC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-1123290-A1 | 3-(SUBSTITUTED PHENYL)-5-THIENYL-1,2,4-TRIAZOLE COMPOUNDS WITH ACTIVITY AGAINST WHITEFLY | Dow AgroSciences LLC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6265424-B1 | INSECTICIDES, MITICIDES | DOW AGROSCIENCES LLC | 2001-07-24 | — | — | US | disclosed |
| US-6096898-A | One pot synthesis of 1,2,4-triazoles | DOW AGROSCIENCES LLC (US) | 2000-08-01 | — | — | US | disclosed |
| WO-2000024738-A1 | PROCESS FOR PREPARING 3-(SUBSTITUTED PHENYL)-5-THIENYL OR FURYL)-1,2,4-TRIAZOLES AND NOVEL INTERMEDIATES UTILIZED THEREIN | DOW AGROSCIENCES LLC (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-2000024737-A1 | 3-(SUBSTITUTED PHENYL)-5-THIENYL-1,2,4-TRIAZOLE COMPOUNDS WITH ACTIVITY AGAINST WHITEFLY | DOW AGROSCIENCES LLC (US) | 2000-05-04 | — | — | WO | disclosed |
| US-3976769-A | INSECTICIDE | AIRWICK INDUSTRIES, INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171408-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F12, CHRM1, NPY1R | GAA 2142/4885ITGB2 860/4885ICAM1 4815/4885 |
| US-20120202788-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F12, CHRM1, NPY1R | GAA 2142/4885ITGB2 860/4885ICAM1 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.