Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801674 | 0.83 | KMT2A (0.49) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL13140637 | 0.81 | KMT2A (0.52) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL13140602 | 0.81 | LMNA (0.49) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL628630 | 0.80 | LOXL2 (0.50) | MEN1KMT2AMAPTALDH1A1HSD17B10 | |
| SCHEMBL6624770 | 0.80 | SLC6A3 (0.46) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL6774395 | 0.79 | SLC6A3 (0.44) | MEN1KMT2AMAPTALDH1A1HSD17B10 | |
| SCHEMBL630123 | 0.79 | SLC6A3 (0.43) | MEN1KMT2AMAPTALDH1A1FNTA | |
| SCHEMBL6625716 | 0.79 | SLC6A3 (0.43) | MEN1KMT2AMAPTALDH1A1HSD17B10 | |
| SCHEMBL7905941 | 0.79 | FNTA (0.44) | KMT2AFNTAFNTBSLC6A2SLC6A4 | |
| SCHEMBL628950 | 0.78 | SRD5A2 (0.48) | ALDH1A1SLC6A2SLC6A4SLC6A3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |
| WO-1998050030-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |