Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.69 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.69 |
| ▸ | HTR3B | O95264 | 3/20 | 0.69 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.69 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.69 |
| ▸ | HTR5A | P47898 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28728953 | 0.90 | HTR3A (0.67) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL10521605 | 0.85 | DRD2 (0.64) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7436348 | 0.82 | HTR4 (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL29567897 | 0.82 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL16003 | 0.82 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| (R)Zacopride SCHEMBL5387843 | 0.82 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL5373467 | 0.82 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL8870896 | 0.81 | HTR4 (0.62) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL7280994 | 0.81 | MAPK1 (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL667580 | 0.81 | MAPK1 (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853376-A | Benzamides and benzoates having anti-emetic activity | BEECHAM GROUP, P.L.C. (GB) | 1989-08-01 | — | — | US | claimed |
| EP-0221702-A2 | Quinolidine derivatives | BEECHAM GROUP PLC (GB) | 1987-05-13 | — | — | EP | claimed |
| US-6221878-B1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE (5-HT) AT 5-HT3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2001-04-24 | — | — | US | disclosed |
| US-5420139-A | Administering 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxybenzamide | GLAXO GROUP LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5330982-A | Promote gastric emptying | GLAXO GROUP LIMITED (GB) | 1994-07-19 | — | — | US | disclosed |
| US-5298510-A | Relief of side effects resulting from drug withdrawal, treatment of addiction, indole derivatives | GLAXO GROUP LIMITED (GB) | 1994-03-29 | — | — | US | disclosed |
| US-5246941-A | Serotonin antagonist | GLAXO GROUP LIMITED (GB) | 1993-09-21 | — | — | US | disclosed |
| US-5244909-A | Methods for the treatment of cognitive disorders | GLAXO GROUP LIMITED (GB) | 1993-09-14 | — | — | US | disclosed |
| US-5200414-A | Adiminstering endo-N-(8-methyl-8-azabicyclooct-3-yl)-2,3-dihydro-3,3-dimethyl-indole-1 -carboxamide as a 5-hydroxytrypt-amine antagonist | GLAXO GROUP LIMITED (GB) | 1993-04-06 | — | — | US | disclosed |
| US-5198447-A | Aid for withdrawal from drugs, alcohol, cigarettes | GLAXO GROUP LIMITED (GB) | 1993-03-30 | — | — | US | disclosed |
| US-5190954-A | 5-Hydroxytryptamine Antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-02 | — | — | US | disclosed |
| US-5071854-A | Hydroxytryptamine antagonists | GLAXO GROUP LIMITED (GB) | 1991-12-10 | — | — | US | disclosed |
| US-4985437-A | 5-HYDROXYTRYPTAMINE ANTAGONISTS, COGNITION ACTIVATORS | GLAXO GROUP LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4973594-A | TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 1990-11-27 | — | — | US | disclosed |
| US-4948803-A | USING AZABICYCLOINDAZOLE-3-CARBOXAMIDES | GLAXO GROUP LIMITED (GB) | 1990-08-14 | — | — | US | disclosed |
| US-4853376-A | Benzamides and benzoates having anti-emetic activity | BEECHAM GROUP, P.L.C. (GB) | 1989-08-01 | — | — | US | disclosed |
| EP-0221702-A2 | Quinolidine derivatives | BEECHAM GROUP PLC (GB) | 1987-05-13 | — | — | EP | disclosed |