Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502733 | 0.86 | KDM4E (0.55) | KDM4ETP53SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL16503496 | 0.83 | HTR2C (0.43) | KDM4ETP53SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL7920176 | 0.80 | CCR1 (0.46) | KDM4ETP53SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7917427 | 0.79 | F2 (0.41) | KDM4ESMN1; SMN2MAPK1NPC1ALDH1A1 | |
| SCHEMBL7915349 | 0.79 | ALOX15 (0.52) | KDM4ETP53SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL7920129 | 0.79 | TNF (0.45) | KDM4ETP53SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL28065836 | 0.77 | CCR1 (0.51) | KDM4ETP53SMN1; SMN2MAPK1NPC1 | |
| SCHEMBL16503471 | 0.77 | DOT1L (0.39) | KDM4ETP53SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16502849 | 0.77 | HTR5A (0.48) | HTR2CPLAU | |
| SCHEMBL12626761 | 0.76 | KDM4E (0.52) | KDM4ETP53SMN1; SMN2MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |